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doi: 10.3389/fcvm.2021.723886 Received 11 June 2021 Accepted 14 October 2021 Published 23 November 2021 Volume 8 - 2021 Edited by Dianjianyi Sun, Peking University, China Reviewed by Nhat Tu Le, Houston Methodist Research Institute, United States

Recalls & Warnings January 21, 2018 Joint Supplement Recalled for Salmonella Risk On January 21, 2018, Arthri-D, LLC announced a recall of its joint pain supplement, Arthri-D (120 count), due to possible Salmonella contamination

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Studies suggest PEA may help support relief from neuropathic discomfort, sciatica, lower back pain, and carpal tunnel symptoms without common sedative effects

However, although this supplement is easily available without a prescription in energy drinks, health food stores, or as a protein supplement, this does not mean that it is necessarily benign or free from adverse effects