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12.Siniscalchi, A., Gallelli, L., Labate, A., Malferrari, G., Palleria, C., & De Sarro, G

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H.NovotnyJ

Mechanistic studies reveal that neuronal ferroptosis susceptibility stems from three synergistic factors: high baseline iron retention in substantia nigra and hippocampal regions, GPX4 expression levels 40% lower than in glial cells, and preferential accumulation of polyunsaturated fatty acids in neuronal membranes (Sharma and Flora, 2021)

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In this study of 545 patients with type 2 diabetes, TIR showed a strong negative correlation with HbA1c, indicating its potential as both a short-term and long-term diabetes management marker