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2023B0303000026), Major Talent Program of Guangdong Provincial (Grant No

Qin J, Li Y, Cai Z, et al

Roles of MMPs in ECM remodelling The regular interaction between ECM proteins, proteases, and protease inhibitors contributes to defining the protease:antiprotease ratio, which determines the rate of ECM remodelling [23, 29, 30]

OA-causing factors such as age and mechanical stress lead to excessive oxidative stress in chondrocytes 37,38

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For instance, Behnammanesh et al., proved that canagliflozin, but not empagliflozin or dapagliflozin, inhibits VSMCs proliferation and migration in pharmacologically relevant concentrations (Behnammanesh et al
