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273 The agent C82 suppresses the activity of Wnt/-catenin through blocking the interaction of the protein CBP with -Catenin

The absence of serious adverse events in short-term trials does not establish long-term safety, particularly given the compound's prolonged use in underground communities

Treated aged mice showed restored coat density, better kidney markers, and improved physical activity

Contraindications and Precautions: AOD-9604 should be avoided or used only under close medical supervision in individuals with active malignancy or history of cancer, as the effects of the peptide on tumor growth have not been adequately studied

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ATVBAHA120305565 (2020)