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SPP1+ tumor-associated macrophages drive immunotherapy resistance via CD8+ T-Cell dysfunction in clear cell renal cell carcinoma

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During the dosing phase, treatment-related transient microscopic findings were confined to the injection site and included subcutaneous haemorrhage, mixed-cells inflammation, and necrosis of the skin, subcutaneous tissue and underlying muscle in both sexes (Supplementary Data 4 and 5), accompanied by transient haematological changes (Supplementary Table 8, Supplementary Data 6)

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