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Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds (Fig

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The peak functionality of iHLOs at Day 30, evidenced by maximal expression of CYP450 enzymes like CYP3A4, CYP2B6, and CYP2C9, revealed optimal conditions for xenobiotic metabolism studies

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Theoretical concerns include growth factor-related effects in individuals with existing malignancies and immune modulation in vulnerable populations

this can eventually lead to cell death and increase colonic epithelial permeability, which induces the occurrence of CDAD (Wetzel and McBride, 2020)