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Giurgea in 1972/1973 [10,11] to describe substances that primarily activate cognitive functions, such as memory and learning, especially in situations where these functions are impaired [1]

When applied to specific areas, the peptide acts locally on fat cells without significant systemic absorption

Under conditions of iron overload, the effects of iron on chondrocytes, osteoclasts, osteoblasts, and the cells in the synovial lining have been recently investigated in vitro

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It also impairs base and nucleotide excision repair pathways and causes widespread epigenetic dysregulation, such as aberrant DNA methylation and histone modification, that silence tumor suppressor genes [176]

Nature Geoscience