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Probably, the peptides can exhibit different specificities against microorganisms, as observed in mice [151], or the expression level of the -defensin genes along the intestinal tract shows large variations to optimize the local regulation of bacterial colonization [153]

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GLP-1R/GIPR/GCGR Triple-Agonists Treatment Tri-agonist analogs, which activate the glucagon, GLP-1, and GIPRs, have been developed with the aim that the additional GIP activity will further offer better protection from glucagon-induced hyperglycemia

Standard human dosing protocols based on animal studies suggest 0.25-0.5 mg daily via subcutaneous injection for 4-8 weeks

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