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118 Future clinical trials for fetal engraftment might need to include immunosuppression and avoid patients with established LID to increase the likelihood for successful transplantation, a strategy that has been adopted by various ongoing and upcoming clinical trials

Induced genomic instability leads to various delayed consequences including, lethal mutation, chromosomal instability and mutagenesis (Suzuki et al., 2003)

S.KuskonmazB.et al (2022)

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The complete approval process consists of five major stages: preclinical toxicology studies, Phase I human safety and tolerance testing, Phase II efficacy evaluation, Phase III large-scale controlled clinical trials, and GMP manufacturing site audits

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