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This may result in an accumulation of harmful estrogen metabolites, increasing the risk of symptoms like mood swings, fatigue, or more serious conditions over time

They were also asked if they were taking supplements that contained Vitamin-B and were excluded unless they agreed to stop taking them for the duration of their participation in the study

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PL oS One 6 , e15767 (2011)

This metabolic shift is neuroprotective, reducing oxidative stress, inhibiting A plaque formation, attenuating neuroinflammation, and improving cognitive performance in animal models and early clinical investigations (Rusek et al., 2019