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doi: 10.1016/j.febslet.2007.05.071

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This short phase IIa IMODALS trial, as a prelude to the phase IIb/III MIROCALS trial, showed that low-dose IL-2 (aldesleukin) produces a robust upregulation of the peripheral T reg cell count and a lowering of at least one inflammatory mediator (MCP-1/CCL2)