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EC 2.5.1.18) superfamily, notably members of the plant specific phi (F), tau (U), lambda (L) and dehydroascorbate reductase (DHAR) classes, as well as theta (T), zeta (Z) enzymes ( in planta as the respective proteins and show both a complex regulation and sub-cellular localization ( in vitro , we know relatively little of the function of these proteins in planta ( Arabidopsis thaliana ( At ) as a model, it has been recognized for some time that the large families of At GSTUs and At GSTFs ( At GSTF12 is involved in the regulation of anthocyanin accumulation ( At GSTU20 modulates responses to light reception ( At GSTU17 plays a regulatory role in seedling development ( In the case of At GSTF12, biochemical function can be linked to the observed phenotype of the knock-out, as inferred through metabolic profiling of the flavonoids present in the respective transparent testa 19 (TT19) mutants ( tt19 mutants, which are defective in functional At GSTF12 expression, were deficient in anthocyanin and anthocyanidin pigments, while showing elevated levels of flavonol intermediates as compared with wild type plants

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(ii) Ferroptosis may have occurred in certain anti-inflammatory immune cells in AT, which allows a large increase in pro-inflammatory immune cells, further causing systemic inflammation and insulin resistance, and ultimately leading to the development of obesity

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