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Neuro-immune crosstalk in CNS diseases

D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate

Expression of OL subtype markers was done using adenomatous polyposis coli clone CC1 (APCCC1) (mature OLs) and platelet-derived growth factor receptor (PDGFR) (immature OLs)

This selectivity represents a paradigm shift in antioxidant therapy: Hydroxyl radical specificity : Molecular hydrogen primarily neutralizes hydroxyl radicals (OH), considered the most cytotoxic reactive oxygen species with no known endogenous detoxification system, while leaving beneficial oxidative molecules intact

S-glutathionylation has been shown to regulate the activity of numerous transcription factors and signaling proteins, including those in the NF-B, AP-1, and MAP kinase pathways (e.g., JNK, p38)