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Additionally, metabolic constraints within the TME, including glucose deprivation, 491 amino acid competition, 492 and lipid accumulation, further impair T cell activity

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This process may ultimately affect the brains interoceptive network, particularly the insular cortex, resulting in altered perception and processing of signals related to fatigue and pain

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All three series have shown varying degrees of efficacy in specific tissues, such as the lungs, brain, and cardiovascular system (Day, 2004)