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In the reported cases, the clinical presentation consisted of recurrent episodes of Reye-like encephalopathy, hypoketotic hypoglycemia, and/or cardiomyopathy

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These observational studies should not be discounted

After approximately three weeks, 66% of the patients experienced significant clinical improvements

The concentration of above carnitines was negatively correlated with the score of the Hamilton scale (33)

Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice