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However, when antioxidative systems become saturated, RBCs accumulate oxidative lesions, provoking biochemical alterations and advancing pathological developments ( 2 O 2 can diffuse out of erythrocytes and provoke inflammatory activation in the lungs microvascular endothelium ( 2 O 2 and hydroxyl radicals inflict damage on erythrocyte membrane proteins and lipids, resulting in reorganization of the cytoskeleton, loss of membrane stability and deformability, and eventually eryptosis (Sudnitsyna et al., 2020)

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doi: 10.1002/jcla.24326 344 KamiskaKStenclikDBaejewskaWBogdaskiPMoszakM

The clinical presentation of CHE is highly variable and encompasses a broad spectrum of morphologic (phenotypic) subtypes, which are distinct from the underlying etiologic classifications such as atopic, irritant, or allergic contact dermatitis [3, 9]

Consequently, this amino acid is often depleted in cell cultures that are contaminated with Mycoplasma

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