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The theoretical cancer concern carries less weight in this population

[DOI] [PubMed] [Google Scholar] 31.Cervelli M., Amendola R., Polticelli F., Mariottini P

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BPC157 exists in a gray area legally not banned, but not FDA-approved for human use in the United States

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Thus, we posit that the dose of APR-246 needed to sufficiently restore wildtype function and overcome dominant negative effects of remaining p53 mutants is the major limitation in these studies