source naturals acetyl l-carnitine and alpha-lipoic acid 3 Packs Best 1000mg Capsule, 60 Count Acetyl L-Carnitine Free Form 400

Mutations in genes encoding other components of the PDHc, including the PDHB gene and the DLAT gene, have been shown to be associated with PDH deficiency syndromes

PMID: 58 GaoJLiJLuoZWangHMaZ

Energy production (metabolism) Neurological (brain) function Vitamin B12 plays a key role in the normal functioning of the brain and nervous system

[DOI] [PubMed] [Google Scholar] 394

If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 supplements

Another enzyme is AHCY, which converts S-adenosylhomocysteine (SAH) to homocysteine and interacts with the CLOCK-BMAL1 complex, playing a key role in circadian regulation [35]