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The authors concluded that GHK-Cu accelerates wound healing and skin repair through coordinated effects on collagen and glycosaminoglycan turnover, modulation of metalloproteinase activity, attraction of immune and endothelial cells to injury sites, and restoration of replicative vitality in irradiated fibroblasts [1]

while this risk is less relevant for injectable forms, caution is still advised in patients with reactive airway diseases

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Heres why transdermal delivery is especially effective for acne: 1

PLoS ONE 8 , e54014 (2013)
