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PDE4 isoforms regulate cAMP signaling resulting from 1AR and 2AR stimulation in cardiac myocytes

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In general, by either excess or impairment, NO appears to cause or contribute to a variety of disturbances, in particular, hypertension, angina, impotence, circulatory shock, septic shock, stroke, inflammation, respiratory distress syndromes, pulmonary hypertension, adhesion and aggregation of platelets and leukocytes, diabetes, hypotension, and Parkinson's disease

2008;153(Suppl 1):S68-75

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