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It was a setback, but as it often happens in science, it was not the end of the road for AOD-9604, paving the way for a new and unexpected chapter in its story

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

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Other studies have shown that vitamin E has no protective effects against DA-induced toxicity in PC12 cells (Offen et al., 1996) and only partial protection in MPTP-treated rodents (Perry et al., 1987)

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