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Description
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However, the intended dose escalation of CAR T cells was hindered by on-target toxicity, which cause cystitis

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10.1371/journal.pone.0057610 PLoS One 96 MunnD

Trends Immunol 32:350357

The two active sites of TIGAR are open, positively charged and can bind to other small molecules (Li and Jogl, 2009)
