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PKM2 drives hepatocellular carcinoma progression by inducing immunosuppressive microenvironment

In conclusion, we have shown that it is possible, with a small number of mutations (four in this case), to engineer an isopeptide bond crosslink into a protein that lacks any of the requisite residues at the selected site

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Thus far, although immune cells have become the focus of most research, it is increasingly clear that intestinal epithelial cells play an important role in the pathogenesis and progression of UC