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All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)
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Gorelik Y, Freilich S, Gerassy-Vainberg S et al (2021) Antibiotic use differentially affects the risk of anti-drug antibody formation during anti-TNFalpha therapy in inflammatory bowel disease patients: a report from the epi-IIRN

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Some studies suggest that probiotics may help alleviate regurgitation and improve the quality of life for individuals with GERD