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In contrast, Gepon exposure only caused minimal and statistically insignificant increases in SMAD2 phosphorylation, suggesting that it does not effectively trigger the canonical pathway

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On the contrary, excessive ROS levels cause cell injury by damaging proteins, lipids, and nucleic acids, leading to different conditions, such as neurological diseases, hypertension, diabetes, atherosclerosis, heart failure, chronic kidney disease, and cancerogenesis [2]

Yi-Wei Huang is with the Department of Dermatology at National Taiwan University Hospital in Taipei, Taiwan

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