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The loss of barrier integrity allows bacteria and other antigens to penetrate the intestinal barrier

It is an undesirable side effect of pharmacotherapy, characterized by symptoms such as changes in mental state, autonomic disturbances, or neuromuscular disorders

S., Spitz, D

doi:10.4103/ijem.ijem_45_24 Kruse T, Hansen JL, Dahl K, et al

Animals were then challenged with a graduated fatigue test, beginning at 10 m/min and 4% grade for 3 min, and increasing in speed by 2 m/min every 2 min to a max speed of 16 m/min until exhaustion