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Key finding: AOD 9604 (0.1-10 mcg/kg) promoted cartilage repair with 52% defect filling versus 8% in controls

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The STEP 4 withdrawal trial demonstrated that continued Semaglutide therapy was needed to maintain weight loss, as patients switched to placebo regained weight over 48 weeks (Rubino et al., JAMA 2021

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The following organs were collected during the sacrifice procedures: liver, kidney, heart and brain