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The mutant forms of this protein fixate a much smaller amount of metals than the usual form, which results in the formation of an excess of peroxynitrite (ONOO ) affecting the motor neurons required for normal functioning, causing severe motor disorders (Pasinelli et al., 2004)

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Pina-Oviedo S, Shroff GS, Strange CD, Ahuja J, Sabloff BS, Debiane LG, Peralta AR, Cohen A, Simoff MJ, Mehta V, Diaz-Mendoza J, Brasher WP, Faiz SA, de Groot PM, Truong MT

Second, the success of regenerative approaches hinges on Functional Integrationthe guarantee that stem cell-derived beta cells will not only survive long-term after transplantation but also achieve full functional maturity and maintain exact, dynamic glucose-responsive insulin secretion

2 Remarkably, DTP cancer cells exhibit significant similarities to embryos under stress, including the distinct metabolic pattern, stemness maintenance, and transient cell cycle arrest

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