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At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)

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Thus, the application of LOX genes and proteins on disease diagnosis, treatment and prognosis are required to be further investigated

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Upon stimulation, Nrf2 is translocated into the nucleus after dissociation from Keap1 (Itoh et al., 1999)