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In the mosquito Aedes aegypti , this melanization pathway in response to filarial infection is diminished, suggesting parasite manipulation of this critical response 25,27,44

Lentigines assume a particular importance when their presence is associated with a variety of inherited systemic conditions, including Peutz-Jeghers, LEOPARD (multiple lentigines), and Carney syndromes, centrofacial lentiginosis, and Laugier-Hunziker syndrome (idiopathic lenticular mucocutaneous pigmentation)

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Yu C et al

Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease

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