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Cook, DG Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction Sci Transl Med 8 321: 321ra6

640 In the DPN study, tanezumab provided effective pain reduction in DPN, with no safety concerns observed

Some patients notice appetite changes within the first few weeks, while weight changes may occur more gradually

These effects may result from an improved inflammatory status, inhibition of the muscle catabolic pathways and/or stimulation of the anabolic pathways

Post-transcriptional/Translational Modifications of BCAT2 Except for the relatively well studied effects of branched-chain ketoacid dehydrogenase kinase (BDK) and PP2Cm on the E1 subunit of BCKDH (please see section BCKDH Regulation in Muscle), not much is known about posttranslational modifications of enzymes that catabolize BCAAs