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The liver relies on glutathione for detoxification reactions and for buffering oxidative byproducts created during normal metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Hitchon C.A., El-Gabalawy H.S

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However, in neurodegenerative conditions, impaired mitochondrial function leads to increased ROS generation and a diminished capacity to neutralize them, resulting in the accumulation of ROS and elevated oxidative stress within brain cells [67,68,87]