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Hydrolysis of cysteinylglycine and of cysteinylglycine S -conjugates formed from the -glutamyl transpeptidase-mediated degradation of GSH and GS-conjugates, respectively, is mediated by various dipeptidase activities, including the plasma membrane-bound ectoenzyme aminopeptidase N (Figure 1C), and cytosolic leucyl aminopeptidase (EC 3.4.11.1

Targeted therapies that include Bcl- 2 inhibitors have improved apoptosis, yet the development of resistance has constrained the utility of these therapies (Lampson and Davids 2017)

Synthetic mRNAs, which transiently express functional cystinosin, have demonstrated beneficial and sustained impacts on proximal tubular resorptive function, proteinuria, and kidney morphology in zebrafish after treatment [157]

Avoid processed foods that are fortified with synthetic folic acid, as they can be problematic for those with MTHFR mutations
