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Description
A large preclinical toxicity program run across mice, rats, rabbits, and dogs found BPC-157 well tolerated with no serious treatment-related toxicity, no identifiable lethal dose, and no genotoxic or teratogenic signal, which is the strongest safety data point available by Xu 2020
The endpoints of this exploratory study were change at wk 4 in (a) pain level, as assessed by the BPI and SF-36
Consequently, its rapid metabolism into active fragments and lack of systemic accumulation highlight a strong clearance profile, reducing the potential for peptide build-up or toxicity
10.1016/j.mce.2011.07.010 Mol
hs-CRP: a systemic inflammation marker
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