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Egashira N, Shirakawa A, Abe M, Niki T, Mishima K, Iwasaki K, et al

To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity

For example, whereas sulphide-oxidising activity is virtually undetectable in nervous system cells, colonocytes display high expression and activity of SOP enzymes, 131,132,133 consistent with the high H 2 S concentrations that result from gut microbial metabolism

However, this modification also disrupts CaM-KII binding (OLeary et al., 2011)

Solfrizzi, V
