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doi: 10.1016/j.cell.2013.12.012 [DOI] [PMC free article] [PubMed] [Google Scholar] 27

10.1158/2159-8290.CD-19-0959 152 PatriarcaE

Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents
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[DOI] [PMC free article] [PubMed] [Google Scholar] 647.Kim J.K., Gimeno R.E., Higashimori T., Kim H.J., Choi H., Punreddy S., Mozell R.L., Tan G., Stricker-Krongrad A., Hirsch D.J., et al

50 M Ag alone exhibited no discernible impact on the activation status of JS-1, while 12.5, 50, 75 M Ag had significant inhibitory effects on the TGF-1-induced activation of JS-1
Therefore, GSTP1 methylation appears to play a key role in numerous diseases