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The context of pathway activation matters enormously

For instance, isobaric metabolites or structural isomers cannot readily be differentiated from each other solely based on the beforementioned physicochemical parameters due to (i) co-elution, (ii) similar MS, or (iii) MS2 spectral data

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Glutamine-derived aspartate upregulates HIF-1 expression via the polyamine synthesis pathway and the hypusination of eIF5A Glutamine-derived aspartate is either converted to argininosuccinate via argininosuccinate synthase 1 (ASS1) and then incorporated into the urea cycle or used by asparagine synthetase (ASNS) to synthesize asparagine 21,22,34

2019 Apr 1 [cited

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture