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Ecotoxicol Environ Saf 72:11021110 Sidhu GPS, Bali AS (2021) Thiol-dependent metal hyperaccumulation and tolerance in plants

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Increased ROS also activate STAT1 triggering the inflammatory process in the cochlea (Kaur et al., 2011), and the binding of inflammatory cytokines to their receptors further leads to an increase in ROS production in OHC cells.ROS and inflammatory responses reinforce each other, forming a positive feedback loop that further exacerbates OHC damage (See Figure 3)