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Clin Endocrinol (2010) 72:37782

For this reason, drugs with a long half-life (e.g., amiodarone, elimination t 1/2 of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly

For dorsal (back of wrist) tendon issues: Inject subcutaneously 1-2 inches proximal to the area of maximum tenderness

Although rescue medication was allowed in all four studies, patients were instructed not to use them during the four-hour observation period