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First, because the last enzyme (GLDH enzyme) of the L-galactose pathway is a component of the mitochondrial complex I, thus its catalytic activity could be regulated by the electron flow across this protein complex

Since most of the physiological properties of the GL are determined by the degree of GAG sulfation, ways to optimise inorganic sulfate, the rate-limiting substrate for sulfation, should be the primary focus of treatment

doi: 10.1016/j.exger.2016.02.013 [DOI] [PMC free article] [PubMed] [Google Scholar] 413

As expected (70), these diagnoses do not seem to follow predictable Mendelian patterns, suggesting that there are multiple genes and alleles that increase the risk of developing ME/CFS (56)

Think Long-Term: Real cellular change happens over months, not days

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