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This was done to determine if the observed mutations were responsible for the change in the dynamics of resistance acquisition

8 In a 2013 mixed-methods, descriptive, cross-sectional study on self-care strategies for CIPN reported by colorectal cancer survivors treated with oxaliplatin, a host of self-management strategies were documented that warrant further investigation for nonpharmacologic treatment options that are easily accessible, safe, and effective

Common denaturants that have been successfully employed include guanidine HCl, urea, Tween 20, CTAB, and SDS (17, 18)

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