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Interestingly, analysis of the datasets from Oncomine cancer microarray database confirmed a lower PLC expression in the lung adenocarcinoma tissues as compared to the respective normal tissues suggesting rather tumor suppressor role of this protein for lung tumor development [26](Figure 2B)

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Morphological and functional metabolism studies link chronic pain and depressive disorders to dysfunctional neuroplastic changes in fronto-limbic brain regions that control emotional responses to painful injuries and stressful events