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doi:10.1186/gm368

424426, Apr

SOD is the first member of the antioxidant defense system via catalyzing the dismutation of the superoxide anion to oxygen and hydrogen peroxide (H 2 O 2 ), which is then metabolized by GSH-Px [76]

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Whether this mechanism is commonly employed for a variety of substrates and whether monothiol mechanisms (i) and (ii) are really relevant for the reduction of other non-glutathione disulfide substrates remains to be analyzed

Elevated PSAT expression and increased serine levels have been observed in the colons of patients with IBD and in DSS-treated mice, where they promote mucosal regeneration by enhancing wound healing and crypt cell proliferation 62