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ROS mediates lipid peroxidation, which leads to tissue damage development after MTX administration

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DAMPs can not only bind to pattern recognition receptors (PRR) to subsequently promote adaptive immunity by inducing DC activation, but can also enhance adaptive immune responses by affecting the presentation of antigens associated with dying cells, promoting phagocytic action ( eat-me signaling, e.g., calreticulin), and facilitating antigen extraction and processing ( present-me signaling, e.g., F-actin or HMGB1) (111, 115, 117)

For example, UW solution contains HES (a polysaccharide) and lactobionic acid (a disaccharide)

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In guinea pigs fed a high-cholesterol diet, dietary inclusion of moringa leaves (2 or 3.5 g/day) significantly reduced hepatic cholesterol and triglyceride levels, inflammatory cytokines (IL-1, IL-10, IFN-), and histologically evident liver steatosis, without altering plasma lipid profiles