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Whether parallel alteration in platelet responsiveness and long-term thrombosis risk occurs in subjects remains to be determined, but as noted above, elevated serum levels of carnitine are associated with enhanced risks of major adverse cardiovascular events (6)

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It was found that PGC-1 possesses dual activities stimulating mitochondrial electron transport while susppressing ROS, and may serve as an adaptive set-point regulator, capable of providing an accurate balance between metabolic requirements and cytotoxic protection from the ensuing consequences of increased ROS activation [8]

(PubMed) Nathan DM, Davidson MB, DeFronzo RA, et al

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