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A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms

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Commun Chem

After comparison of the redox titrations of ROXY9 and GRXC2 with either GSH/GSSG or DTT/dithiane, we had concluded that GRXC2, but not ROXY9, accepts low amounts of GSSG as a substrate for an oxidative half-reaction because of its favourable scaffold site leading to glutathionylation at Cys A