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The cold atmospheric plasma (CAP) technique combined with iron oxide-based magnetic nanoparticles downregulated epidermal growth factor receptor (EGFR) and inhibited lung cancer cells by depressing pERK and pAKT (Li et al., 2019)

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Asia Pacific Journal of Clinical Nutrition, 2(3), 111114

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10.1007/s00430-021-00727-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 334.Hsu R-J, Yu W-C, Peng G-R, Ye C-H, Hu SY, Chong PCT, et al

We found that lactate, taken up and oxidized by the mitochondrial cluster of differentiation 147 (CD147)/monocarboxylate transporter 1 (MCT1)/lactate dehydrogenase B (LDHB) complex, was converted into the tricarboxylic acid (TCA) cycle intermediate -ketoglutaric acid (-KG), which subsequently induced MIC stemness potentials via DNA methyltransferase 3 beta (DNMT3B)-mediated SOX2 hypomethylation