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Any net-like purple discoloration or skin changes that dont follow the normal bruise progression from blue to green to yellow should also be evaluated

Going repeatedly between strong air conditioning and humid outdoor heat causes vascular reactivity in the face, which manifests as visible flushing and aggravates baseline PIE

Other common side effects include: Dizziness Diarrhea Constipation Changes in taste Low levels of vitamin B12 (if taken for a long time) Famotidine and constipation Constipation is an uncommon side effect of famotidine, occurring in only 1-2% of users

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For long-term studies or to prevent degradation from repeated freeze-thaw cycles, it is best practice to aliquot the freshly reconstituted solution into single-use volumes and store them frozen at -20C or colder

Re-using a syringe is another