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9 Approval of sorafenib (multi-kinase inhibitor of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and Raf kinases) was the first systemic therapy to conclusively demonstrate an improvement in overall survival in patients with advanced HCC

Skin-lightening products can further incorporate anti-inflammatory agents such as licorice extract or dipotassium glycyrrhizate, and/or actives that remodel and improve skin structure such as hyaluronic acid, glycolic acid, or proxylane [203, 213]

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Nevertheless, more diverse vaginal microbiomes have been observed globally across different healthy populations (North America 146 , Scandinavia 147 , South Africa 148 , and Kenya 149 ), but are usually associated with adverse sexual and reproductive outcomes 150