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In addition to regulating the ubiquitination of muscle proteins, L-carnitine also increased the levels of p-p70S6K and p70S6K, which are involved in protein synthesis

The balance of the carnitine pool is essential for maintaining organ function and is a promising target for the intervention and treatment of diseases

Fecal tests from metformin-treated donor mice showed that recipient mice had increased Bifidobacterium bifidum and Akkermansia, and decreased CutC/D in their gut microbiota ( Regulating plasma TMAO levels requires a holistic approach, including diet changes, gut microbiota adjustments and medications

The results revealed 45 notable metabolites involved in amino acid, thiamine, nicotinic acid, and pyrimidine metabolism